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MER, POAS and Contribution Margin: How Peptide Brands Should Measure Ad Profit

A 4x ROAS is not the same as profit. This guide explains MER, POAS and contribution margin with a worked example so you can set targets that make money.

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ROAS tells you how much revenue each ad dollar produced. It does not tell you whether you made money. For peptide and supplement brands, with product costs, shipping, refunds and fees, the gap can be large. Three measures close it: MER, POAS and contribution margin.

This is the measurement layer for our paid media strategy guide.

The Definitions

MetricFormulaUse it for
ROASRevenue attributed to ads / ad spendPlatform-level efficiency
MER (marketing efficiency ratio)Total revenue / total marketing spendWhole-business efficiency, independent of attribution
POAS (profit on ad spend)Gross profit from ad-attributed sales / ad spendBidding and budget decisions
Contribution marginRevenue minus product cost, shipping, payment fees, refunds and marketing spendWhether growth is profitable

POAS is ROAS multiplied by your gross margin. A POAS above 1 means the ad spend was covered by the gross profit it generated. Whether that is enough depends on your other costs.

A Worked Example (Illustrative Numbers)

These figures are made up to show the arithmetic. Replace them with your own.

LineAmount
Ad spend$10,000
Revenue attributed to ads$40,000 (ROAS 4.0)
Product cost (35% of revenue)$14,000
Shipping and packaging$3,200
Payment fees$1,200
Refunds and chargebacks$1,600
Contribution after ad spend$10,000

Here, gross margin before shipping and fees is 65%, so POAS is 4.0 x 0.65 = 2.6. After every cost, the business keeps $10,000 on $10,000 of spend. Now imagine product cost at 65% instead: gross margin falls to 35%, POAS to 1.4, and the same 4.0 ROAS leaves the business with a loss after shipping, fees and refunds. The ROAS did not change. The profit did.

Break-Even ROAS

Break-even ROAS is 1 divided by your contribution margin before ad spend. If you keep 50 cents of every revenue dollar after product, shipping, fees and refunds, you break even at 2.0 ROAS. Anything below it loses money, and the profit target sits above it. Compute this for each product line, not once for the whole store.

Set Targets From Margin

  1. Calculate contribution margin per product or bundle. Include every variable cost.
  2. Convert to break-even ROAS using the formula above.
  3. Add the profit you want. A target of 20% above break-even is a starting point to adjust.
  4. Set Target ROAS by product tier. High-margin items can afford more; low-margin items cannot.
  5. Review monthly. Costs, discounts and refund rates move.

This is the same reasoning behind the bidding reset in our plateau case breakdown, where Target ROAS was reset using actual margin data and Shopping was segmented by margin tier.

Why MER Matters Alongside Platform Numbers

Platform attribution can double count across channels or miss sales that arrive after a click-through from another channel. MER ignores attribution entirely: it divides all revenue by all marketing spend. Track it weekly next to platform ROAS. If platform ROAS rises but MER does not, you may be capturing demand you would have had anyway. Better tracking helps, so see our guides to the Meta Conversions API and GA4 enhanced conversions.

What to Put in a Weekly Dashboard

  • Revenue, ad spend and MER
  • Platform ROAS by channel
  • POAS by product tier
  • Refund and chargeback rate
  • Contribution margin after ad spend
  • Policy status and disapprovals (growth that breaks the account is not profitable)

Use this to size spend with our advertising budget guide, plan promotions with our Black Friday guide, and see how structure and margin scale together in our scaling guide.

Frequently Asked Questions

What is the difference between ROAS and POAS?

ROAS is revenue divided by ad spend. POAS is gross profit from ad-attributed sales divided by ad spend, which equals ROAS multiplied by gross margin.

What is MER?

Marketing efficiency ratio: total revenue divided by total marketing spend. It does not depend on platform attribution, so it is a useful check on platform numbers.

How do I calculate break-even ROAS?

Divide 1 by your contribution margin before ad spend. A margin of 50% gives a break-even ROAS of 2.0.

Should I use one ROAS target for the whole store?

No. Margins differ by product and bundle, so set targets by product tier.

Why does profit matter more than ROAS for peptide brands?

Product cost, shipping, payment fees and refunds vary and can turn a healthy-looking ROAS into a loss. Contribution margin shows whether growth is profitable.

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